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Bariatric surgery influences β-Cell turnover in non obese rats

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dc.contributor.authorCamacho Ramírez, Alonso
dc.contributor.authorBlandino Rosano, Manuel
dc.contributor.authorSegundo Iglesias, M. Carmen
dc.contributor.authorLechuga Sancho, Alfonso M.
dc.contributor.authorAguilar Diosdado, Manuel
dc.contributor.authorPérez Arana, Gonzalo M.
dc.contributor.authorPrada Oliveira, J. Arturo
dc.date.accessioned2022-03-18T10:29:19Z
dc.date.available2022-03-18T10:29:19Z
dc.date.issued2017
dc.description.abstractBackground. The aim of this study was to investigate the relation between the different bariatric surgeries and pancreatic β-cell turnover. Material and Methods. We used healthy adult male Wistar rats to undergo the different techniques. Three surgical techniques were developed (malabsorptive, Sleeve gastrectomy and Roux-Y Gastric Bypass-), together with two control groups (Sham and fasting control). Pancreatic β-cell mass was measured, as well as apoptosis, proliferation and neogenesis related to cellular turnover. Otherwise, we measured the functional issues to elucidate the physiological role that these surgical techniques trigger in the carbohydrate metabolism (e.g. food intake, weight gain, intraperitoneal glucose tolerance test, and basal glycaemia). Results included the differences in phenotypes of the rat after the surgery. The rats did not show important differences in glycaemic parameters between the surgical groups. The β-cell mass presented modifications related with proliferation processes. A significant increase of β-cell mass in the malabsorptive technique was reported. On the other hand, the peripheral resistance to insulin tended to be reduced in rats which underwent malabsorptive and mixed techniques. Conclusion. This work showed an increase in β-cell mass after the resection of an important portion of small bowel. The Roux-Y Gastric Bypass produced a non-significant increase in β-cell mass. We considered that these implications of surgery over the endocrine pancreas must be one of the mechanisms related to the improvement of type 2 Diabetes mellitus following bariatric surgery.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationHistology and Histopathology, Vol.32, nº12, (2017)
dc.identifier.doiDOI: 10.14670/HH-11-909
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/118143
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPancreases
dc.subjectDiabeteses
dc.subjectBariatric-surgeryes
dc.subjectInsulin-Secreting Cellses
dc.subjectBeta-cell masses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleBariatric surgery influences β-Cell turnover in non obese ratses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.32,nº12 (2017)