Publication: Vaspin and amylin are expressed in human and rat placenta and regulated by nutritional status
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Date
2009
Authors
Caminos, Jorge E. ; Bravo, Susana B. ; Garcés, Maria F. ; González, C. Ruth ; Cepeda, Libia A. ; González, Adriana C. ; Nogueiras, Rubén ; Gallego, R. ; Garcia-Caballero, Tomas ; Cordido, Fernando ; López, Miguel ; Diéguez, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Amylin (islet amyloid polypeptide) and
vaspin (visceral adipose tissue specific serpin) are gut
and adipocyte hormones involved in the regulation of
body weight homeostasis. The aim of this study was to
examine whether amylin and vaspin are expressed in
human and rat placenta, as well as their regulation by
nutritional status. Our results demonstrate that amylin
and vaspin are localized in both human and rat placenta.
In the rat term placenta vaspin was demonstrated in the
trophoblast of the fetal villi, the labyrinth. Vaspin
immunostaining in human placenta was localized in
cytotrophoblast and syncytiotrophoblast in the first
trimester placentas while in the third trimester vaspin
was localized in the syncytiotrophoblast. Regarding
amylin, rat placenta of 16 days of gestational age
showed an intense immunostaining, mainly localized in
the labyrinth. On the other hand, in the human third
trimester placenta amylin immunoreactivity was intense
in the syncytiotrophoblast of the chorionic villi and in
decidual cells. Furthermore, placental amylin and vaspin
showed an opposite pattern of expression during
pregnancy, with vaspin showing the highest expression
level at the end and amylin at the beginning of
pregnancy. Finally, food restriction also has contrary
effects on their expression, increasing vaspin but
decreasing amylin placental mRNA and protein levels.
Taken together, our results demonstrate that vaspin and
amylin are modulated by energy status in the placenta,
which suggests that these proteins may be involved in
the regulation of placental metabolic functions.
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