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Immunohistochemical localization of hormones and peptides in the human pituitary cells in a case of hipercortisolism by ACTH secreting microadenoma

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dc.contributor.authorReyes, R.es
dc.contributor.authorValladares, Franciscoes
dc.contributor.authorDíaz-Flores, Lucio
dc.contributor.authorFeria, L.
dc.contributor.authorAlonso, R.
dc.contributor.authorTramu, G.
dc.contributor.authorBello, A.R.
dc.date.accessioned2012-05-21T12:10:04Z
dc.date.available2012-05-21T12:10:04Z
dc.date.issued2007
dc.description.abstractThis study assesses the action of hypercortisolism on the hormone and peptide periadenoma region of removed ACTH-producing microadenoma. Our findings show that cortisol excess affects both ACTH and GH production, with no immunoreaction for these hormones. The remaining pituitary hormones (TSH, FSH and PRL) and POMCderived peptides (ßEnd, aMSH and ßMSH) were not modified. Likewise, we observed pituitary immunoreactive cells for Neurotensin (NT), Intestinal vasoactive peptide (VIP), Substance P (SP) and Angiotensin-II (Ang-II). The colocalization demonstrated that NT was expressed in thyrotrope and gonadotrope cells, VIP in gonadotrope cells and SP in corticotrope cells. The results about Ang-II were inconclusive. On the other hand, immunoreaction for the NPY and Gal peptides were not present. In the adenomatous cells, the peptide NT is present in ACTH cells as well as SP. These results suggest a peptide regulation of pituitary cells in the pathological state that can differ between normal and tumoural cells of the same pituitary.es
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dc.format.extent9es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/27603
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCushing’s syndromees
dc.subjectImmunohistochemistryes
dc.subject.other61 - Medicinaes
dc.titleImmunohistochemical localization of hormones and peptides in the human pituitary cells in a case of hipercortisolism by ACTH secreting microadenomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.22, nº 7 (2007)