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Nicotinamide N-Methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinoma

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dc.contributor.authorEmanuelli, Monicaes
dc.contributor.authorSantarelli, Andreaes
dc.contributor.authorSartini, Davide
dc.contributor.authorCiavarella, Domenico
dc.contributor.authorRossi, Valentina
dc.contributor.authorPozzi, Valentina
dc.contributor.authorRubini, C.
dc.contributor.authorLo Muzio, L.
dc.date.accessioned2015-01-20T12:04:12Z
dc.date.available2015-01-20T12:04:12Z
dc.date.issued2010
dc.description.abstractWe investigated expression levels of Nicotinamide N-Methyltransferase (NNMT), an enzyme involved in the biotransformation of many drugs and xenobiotic compounds, in oral squamous cell carcinoma (OSCC). Measurements were performed by immunohistochemistry and the relationship between tumour characteristics and NNMT levels in OSCC was studied to evaluate the effectiveness of NNMT as a prognostic marker in squamous cell carcinoma of the oral cavity. In conclusion, the present study suggests that NNMT may have potential as a biomarker and as a therapeutic target for OSCC.en_EN
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/42568
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectNicotinamidees
dc.subjectN-Methyltransferasees
dc.subject.other61 - Medicinaes
dc.titleNicotinamide N-Methyltransferase upregulation correlates with tumour differentiation in oral squamous cell carcinomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.25, nº1 (2010)