Publication: Morphological changes of myoepithelial cells of
mouse lacrimal glands during postnatal development
Authors
Wang, Y.L. ; Tan, Y. ; Satoh, Y. ; Ono, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
To reveal the correlation between myoepithelial
cell configuration and sizelshape of glandular
endpieces (acini), we observed postnatal developmental
changes of myoepithelial cells in the lacrimal glands of
mice. Glandular and myoepithelial cells were examined
in paraffin sections and in isolated acini. In newborns,
rudiments of acini showed no clear lumina and glandular
cells had few secretory granules. There were no
myoepithelial cells with actin. At 3 days after birth,
some rudiments showed lumina; however, secretory
granules were not salient. Round cells in the periphery of
the acini showed immunoreactivity for actin. In l-weekold
mice, glandular cells were polarized: luminal
cytoplasm contained some secretory granules, and nuclei
were located basally. Most myoepithelial cells were
flattened and sometimes projected thin processes in
various directions. At 2 weeks, the glandular cells
increased their size and contained numerous secretory
granules, and the myoepithelial cells were almost
stellate. In 4-8 week-old mice, acini increased their size,
and myoepithelial cells were very thin and processes
were prolonged in length and increased in number.
During postnatal development, their distribution of
myoepithelial cells was more scarce, while the size of
acini increased. This reciprocal relation of myoepithelial
cell distribution and acinar size may indicate that the
changes of myoepithelial cell configurations depend on
the change of acinus size.
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