Publication:
Effects of phthalate esters on actin cytoskeleton of Py1a rat osteoblasts

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dc.contributor.authorMarchetti, L.es
dc.contributor.authorSabbieti, M.G.es
dc.contributor.authorMenghi, M.
dc.contributor.authorMaterazzi, S.
dc.contributor.authorHurley, M.M.
dc.contributor.authorMenghi, Giovanna
dc.date.accessioned2011-05-11T10:59:13Z
dc.date.available2011-05-11T10:59:13Z
dc.date.issued2002
dc.description.abstractWe evaluated, by confocal laser scanning microscopy, the actin cytoskeleton of immortalized rat Py1a osteoblasts treated with phthalate esters (butyl benzyl phthalate, BBP and dibutyl phthalate, DBP), endocrine disruptors with estrogenic activity. We observed some peculiar modifications of actin cytoskeleton and cells changing from a spindle shape to a rounded form. In particular, F-actin formed thick bundles around the cell membrane but only a weak labeling was observed in rounded cells. Also influence on apoptosis and short-term effects on FGF-2 were studied. It was found that BBP and DBP exert their action in a similar way, act in a transient manner and do not induce apoptosis.es
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dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/20860
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectPhthalate esterses
dc.subjectActines
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::577 - Bioquímica. Biología molecular. Biofísicaes
dc.titleEffects of phthalate esters on actin cytoskeleton of Py1a rat osteoblastses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.17, nº 4 (2002)