Publication: Effects of phthalate esters on actin cytoskeleton of Py1a rat osteoblasts
Authors
Marchetti, L. ; Sabbieti, M.G. ; Menghi, M. ; Materazzi, S. ; Hurley, M.M. ; Menghi, Giovanna
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We evaluated, by confocal laser scanning
microscopy, the actin cytoskeleton of immortalized rat
Py1a osteoblasts treated with phthalate esters (butyl
benzyl phthalate, BBP and dibutyl phthalate, DBP),
endocrine disruptors with estrogenic activity. We
observed some peculiar modifications of actin
cytoskeleton and cells changing from a spindle shape to
a rounded form. In particular, F-actin formed thick
bundles around the cell membrane but only a weak
labeling was observed in rounded cells. Also influence
on apoptosis and short-term effects on FGF-2 were
studied. It was found that BBP and DBP exert their
action in a similar way, act in a transient manner and do
not induce apoptosis.
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