Publication: Chronodisruption and ambulatory circadian monitoring in cancer patients: beyond the body clock
Authors
Almaida Pagán, Pedro Francisco ; Torrente, Maria ; Campos Martínez, Manuel ; Provencio, Mariano ; Madrid, Juan A ; Franco, Fabio ; Rodriguez Morilla, Beatriz ; Cantos, Blanca ; Sousa, Pedro A ; Martinez Madrid, Maria J ; Pimentao, Joao ; Rol, Maria A
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Publisher
Springer
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DOI
https://doi.org/10.1007/s11912-021-01158-z
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info:eu-repo/semantics/article
Description
©2022 The Author(s).
This document is the Published, version of a Published Work that appeared in final form in Current Oncology Reports . To access the final edited and published work see https://doi.org/https://doi.org/10.1007/s11912-021-01158-z
Abstract
Purpose of Review Circadian rhythms impose daily rhythms a remarkable variety of metabolic and physiological functions, such as cell proliferation, inflammation, and DNA damage response. Accumulating epidemiological and genetic evidence indicates that circadian rhythms’ disruption may be linked to cancer. The integration of circadian biology into cancer research may offer new options for increasing cancer treatment effectiveness and would encompass the prevention, diagnosis, and treatment of this disease.
Recent Findings In recent years, there has been a significant development and use of multi-modal sensors to monitor physical activity, sleep, and circadian rhythms, allowing, for the very first time, scaling accurate sleep monitoring to epidemiological research linking sleep patterns to disease, and wellness applications providing new potential applications. Summary This review highlights the role of circadian clock in tumorigenesis, cancer hallmarks and introduces the stateof-the-art in sleep-monitoring technologies, discussing the eventual application of insights in clinical settings and cancer research.
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Citation
Current Oncology Reports (2022) 24:135–149
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1-ene-2999
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