Browsing by Subject "Chronodisruption"

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    Children with obesity have poorer circadian health as assessed by a global circadian health score
    (Springer, 2024-06-08) Rodríguez‑Martín, María; Martínez‑Lozano, Nuria; Santaclara‑Maneiro, Vicente; Gris‑Peñas, Antonio; Salmerón, Diego; Ríos, Rafael; Tvarijonaviciute, Asta; Garaulet, Marta; Ciencias Sociosanitarias
    Background Circadian health refers to individuals’ well-being and balance in terms of their circadian rhythm. It is infuenced by external cues. In adults, a close relationship between circadian-related alterations and obesity has been described. How ever, studies in children are scarce, and circadian health and its association with obesity have not been evaluated globally. We aimed to assess whether circadian health difered between children with and without obesity as determined by a global circadian score (GCS) in a school-age population. Methods Four hundred and thirty-two children (7–12 years) were recruited in Spain. Non-invasive tools were used to calcu late the GCS: (1) 7-day rhythm of wrist temperature (T), activity (A), position (P), an integrative variable that combines T, A, and P (TAP); (2) cortisol; and (3) 7-day food and sleep records. Body mass index, body fat percentage, waist circumference (WC), melatonin concentration, and cardiometabolic marker levels were determined. Results Circadian health, as assessed by the GCS, difered among children with obesity, overweight, and normal weight, with poorer circadian health among children with obesity. Children with obesity and abdominal obesity had 3.54 and 2.39 greater odds of having poor circadian health, respectively, than did those with normal weight or low WC. The percentage of rhythmicity, a marker of the robustness of the TAP rhythm, and the amplitude, both components of the GCS, decreased with increasing obesity. Diferent lifestyle behaviors were involved in the association between circadian health and obesity, particularly protein intake (P=0.024), physical activity level (P=0.076) and chronotype (P=0.029). Conclusions The GCS can capture the relationship between circadian health and obesity in school-age children. Protein intake, physical activity level, and chronotype were involved in this association. Early intervention based on improving circadian health may help to prevent childhood obesity.
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    Chronodisruption and ambulatory circadian monitoring in cancer patients: beyond the body clock
    (Springer, 2022-01-21) Almaida Pagán, Pedro Francisco; Torrente, Maria; Campos Martínez, Manuel; Provencio, Mariano; Madrid, Juan A; Franco, Fabio; Rodriguez Morilla, Beatriz; Cantos, Blanca; Sousa, Pedro A; Martinez Madrid, Maria J; Pimentao, Joao; Rol, Maria A; Fisiología
    Purpose of Review Circadian rhythms impose daily rhythms a remarkable variety of metabolic and physiological functions, such as cell proliferation, inflammation, and DNA damage response. Accumulating epidemiological and genetic evidence indicates that circadian rhythms’ disruption may be linked to cancer. The integration of circadian biology into cancer research may offer new options for increasing cancer treatment effectiveness and would encompass the prevention, diagnosis, and treatment of this disease. Recent Findings In recent years, there has been a significant development and use of multi-modal sensors to monitor physical activity, sleep, and circadian rhythms, allowing, for the very first time, scaling accurate sleep monitoring to epidemiological research linking sleep patterns to disease, and wellness applications providing new potential applications. Summary This review highlights the role of circadian clock in tumorigenesis, cancer hallmarks and introduces the stateof-the-art in sleep-monitoring technologies, discussing the eventual application of insights in clinical settings and cancer research.
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    Chronodisruption and ambulatory circadian monitoring in cancer patients: beyond the body clock
    (Springer, 2022-01-21) Almaida Pagan, Pedro F.; Torrente, María; Campos Martínez, Manuel; Provencio, Mariano; Madrid, Juan Antonio; Franco, Fabio; Rodríguez Morilla, Beatriz; Cantos, Blanca; Sousa, Pedro A.; Martínez Madrid, María José; Pimentao, Joao; Rol de Lama, María de los Ángeles; Fisiología
    Purpose of ReviewCircadian rhythms impose daily rhythms a remarkable variety of metabolic and physiological functions, such as cell proliferation, inflammation, and DNA damage response. Accumulating epidemiological and genetic evidence indicates that circadian rhythms’ disruption may be linked to cancer. The integration of circadian biology into cancer research may offer new options for increasing cancer treatment effectiveness and would encompass the prevention, diagnosis, and treatment of this disease.Recent FindingsIn recent years, there has been a significant development and use of multi-modal sensors to monitor physical activity, sleep, and circadian rhythms, allowing, for the very first time, scaling accurate sleep monitoring to epidemiological research linking sleep patterns to disease, and wellness applications providing new potential applications.SummaryThis review highlights the role of circadian clock in tumorigenesis, cancer hallmarks and introduces the state-of-the-art in sleep-monitoring technologies, discussing the eventual application of insights in clinical settings and cancer research.
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    Impact of a shift work-like lighting schedule on the functioning of the circadian system in the short-lived fish Nothobranchius furzeri
    (Elsevier, 2018-09-02) Almaida Pagán, Pedro Francisco; Ortega-Sabater, C.; Lucas-Sánchez, A.; Martinez-Nicolas, A.; Espinosa, C.; Madrid, J. A.; Rol, M.; Mendiola, P.; Costa, J. de; Esteban Abad, María de los Ángeles; Fisiología
    Adult Nothobranchius furzeri of the MZM-04/10 strain were individually kept and subjected to a “5+2” shifting lighting schedule (SHIFT) for 8 weeks in order to evaluate the desynchronizing effects of a simulated human-like shift-work schedule on the functioning of the circadian system (CS). With this aim, sixteen 21-week-old N. furzeri were placed into a Morning, Night and Evening schedule (lights on from 08:00 to 16:00, 00:00 to 08:00 and 16:00 to 00:00 h, respectively) and fed once a day in the middle of the corresponding photophase (12:00, 04:00 and 20:00 h, respectively). Then, in the weekends (2 days), fish were always returned to the Morning shift. As controls, 16 fish were maintained under a non-shifting LD cycle condition (CONTROL) throughout the whole experiment, with lights on from 08:00 to 16:00 h. Rest-activity rhythm (RAR) of fish subjected to SHIFT showed several symptoms of chronodisruption, such as a decrease in the percentage of diurnal activity and a reduction of the relative amplitude and the circadian function index with time. When a periodogram analysis was performed, RAR of N. furzeri under SHIFT conditions showed up to three separate circadian components: one longer than 24 h (26.5 h) that followed the weekly 8 h delays; a short-period component (~23 h) that was related to the weekend's phase advances, and finally, a 24 h component. The shifting LD schedule also affected fish CS at a molecular level, with several significant differences in the expression of core genes of the molecular clock (bmal1, clock, rorα, rev-erbα) between SHIFT and CONTROL animals. RAR impairment along with changes in clock gene expression could be associated with high stress and accelerated aging in these fish.