Publication:
Current understanding of macrophage type 1 cytokine responses during intracellular infections

Simple item page
dc.contributor.authorXing, Z.es
dc.date.accessioned2011-02-22T11:20:11Z
dc.date.available2011-02-22T11:20:11Z
dc.date.issued2000
dc.description.abstractMacrophages are important effector cells in cell-mediated immunity against intracelllular infection. Among cytokines that macrophages are able to release are IL-12 and TNFa. IL-12 is a critical linker between the innate and adaptive cell-mediated immunity, capable of Thl differentiation and IFNy release by T and NK cells. IFNy is critically required for the activation of macrophage bactericidal activities. Recently emerging evidence suggests that macrophages are able to release not only IL-12 and TNFa but also IFNy. However, the mechanisms that control the release of each of these type 1 cytokines in macrophages appear different. While macrophages release TNFa in an indiscriminate and IL- 12-independent way, the release of IL-12, particularly bioactive IL-12 p70, and IFNy is under tight control. We are just beginning to understand what controls the release of IL-12 p70, a question of fundamental importance to understanding the mechanisms underlying the initiation of cell-mediated immunity. Our recent findings have shed more insights into the regulatory mechanisms of macrophage IFNy responses. It has become evident that IL-12 is required not only for Thl differentiation but also for IFNy responses by both T cells and macrophages during intracellular infection. In this overview, we have discussed about the current understanding of the regulation of macrophage type 1 cytokine responses during intracellular infection, based upon the recent findings from us and others.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19280
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMycobacteriaes
dc.subjectIntracellular infectiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleCurrent understanding of macrophage type 1 cytokine responses during intracellular infectionses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Current understanding of macrophage type 1 cytokine responses during intracellular infections.pdf
Size:
4.73 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.15, nº 1 (2000)