Publication: Current understanding of macrophage type 1 cytokine responses during intracellular infections
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Date
2000
Authors
Xing, Z.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Macrophages are important effector cells in
cell-mediated immunity against intracelllular infection.
Among cytokines that macrophages are able to release
are IL-12 and TNFa. IL-12 is a critical linker between
the innate and adaptive cell-mediated immunity, capable
of Thl differentiation and IFNy release by T and NK
cells. IFNy is critically required for the activation of
macrophage bactericidal activities. Recently emerging
evidence suggests that macrophages are able to release
not only IL-12 and TNFa but also IFNy. However, the
mechanisms that control the release of each of these type
1 cytokines in macrophages appear different. While
macrophages release TNFa in an indiscriminate and IL-
12-independent way, the release of IL-12, particularly
bioactive IL-12 p70, and IFNy is under tight control. We
are just beginning to understand what controls the
release of IL-12 p70, a question of fundamental
importance to understanding the mechanisms underlying
the initiation of cell-mediated immunity. Our recent
findings have shed more insights into the regulatory
mechanisms of macrophage IFNy responses. It has
become evident that IL-12 is required not only for Thl
differentiation but also for IFNy responses by both T
cells and macrophages during intracellular infection. In
this overview, we have discussed about the current
understanding of the regulation of macrophage type 1
cytokine responses during intracellular infection, based
upon the recent findings from us and others.
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