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Lipid droplet associated proteins:an emerging role in atherogenesis

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dc.contributor.authorBuers, Insa
dc.contributor.authorHofnagel, Oliver
dc.contributor.authorRuebel, Anneke
dc.contributor.authorSevers, Nicholas J.
dc.contributor.authorRobenek, Horst
dc.coverage.temporal1992-1995es
dc.date.accessioned2016-04-18T12:35:09Z
dc.date.available2016-04-18T12:35:09Z
dc.date.issued2011
dc.description.abstractCoronary heart disease and stroke, caused by rupture of atherosclerotic plaques in the arterial wall, are the major causes of death in industrialized countries. A key event in the pathogenesis of atherosclerosis is the transformation of smooth muscle cells and in particular of macrophages into foam cells, a result of massive accumulation of lipid droplets. It is well known that the formation of these lipid droplets is a result of the uninhibited uptake of modified lipoproteins by scavenger receptors. However, only more recently has it become apparent that a special set of lipid droplet associated proteins - the PAT protein family (perilipin, adipophilin, TIP47, S3-12 and OXPAT) - is fundamental to the formation, growth, stabilization and functions of lipid droplets. Here we review recent findings and assess the current state of knowledge on lipid droplets and their PAT proteins in atherogenesis.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/48636
dc.languageenges
dc.publisherMurcia: F. Hernándezes
dc.relation.ispartofHistology and Histopathology, vol.26, nº5, 2011es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAtherosclerosises
dc.subjectLipid dropletses
dc.subjectPAT proteinses
dc.subject.other61 - Medicinaes
dc.titleLipid droplet associated proteins:an emerging role in atherogenesises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26, nº5 (2011)