Publication: Lipid droplet associated proteins:an emerging role in atherogenesis
Authors
Buers, Insa ; Hofnagel, Oliver ; Ruebel, Anneke ; Severs, Nicholas J. ; Robenek, Horst
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Coronary heart disease and stroke, caused by
rupture of atherosclerotic plaques in the arterial wall, are
the major causes of death in industrialized countries. A
key event in the pathogenesis of atherosclerosis is the
transformation of smooth muscle cells and in particular
of macrophages into foam cells, a result of massive
accumulation of lipid droplets. It is well known that the
formation of these lipid droplets is a result of the
uninhibited uptake of modified lipoproteins by
scavenger receptors. However, only more recently has it
become apparent that a special set of lipid droplet
associated proteins - the PAT protein family (perilipin,
adipophilin, TIP47, S3-12 and OXPAT) - is fundamental
to the formation, growth, stabilization and functions of
lipid droplets. Here we review recent findings and assess
the current state of knowledge on lipid droplets and their
PAT proteins in atherogenesis.
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