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The role of neuromedin B in the regulation of rat pituitary-adrenocortical function

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dc.contributor.authorMalendowicz, L.K.es
dc.contributor.authorMacchi, C.es
dc.contributor.authorNussdorfer, G.G.
dc.contributor.authorNowak, M.
dc.date.accessioned2011-02-22T10:33:41Z
dc.date.available2011-02-22T10:33:41Z
dc.date.issued1996
dc.description.abstractThe effects of a 7-day administration of neuromedin B (NMB) andlor ( ~ ~D-rphe~12,)-b ornbesin, an NMB-receptor antagonist (NMB-A) on the function of pituitary-adrenocortical axis were investigated in the rat. NMB raised the plasma concentration of aldosterone, without affecting that of ACTH or corticosterone; the simultaneous administration of NMB-A prevented the effect of NMB. Neither NMB nor NMB-A treatments induced significant changes in adenohypophysis and adrenal weights, nor in the average volume of zona glomerulosa and zona reticularis cells. NMB-A administration lowered the volume of zona fasciculata cells, an effect annulled by the concomitant NMB administration. Our results suggest that NMB specifically stimulates aldosterone secretion, and that endogenous NMB or NMB-like peptides exert a tonic stimulating action on the growth of zona fasciculata cells.es
dc.formatapplication/pdfes
dc.format.extent3es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18898
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectNeuromedin Bes
dc.subjectSteroid secretiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleThe role of neuromedin B in the regulation of rat pituitary-adrenocortical functiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.11, nº 4 (1996)