Publication: The role of neuromedin B in the regulation of rat pituitary-adrenocortical function
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Date
1996
Authors
Malendowicz, L.K. ; Macchi, C. ; Nussdorfer, G.G. ; Nowak, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effects of a 7-day administration of
neuromedin B (NMB) andlor ( ~ ~D-rphe~12,)-b ornbesin,
an NMB-receptor antagonist (NMB-A) on the function
of pituitary-adrenocortical axis were investigated in
the rat. NMB raised the plasma concentration of
aldosterone, without affecting that of ACTH or
corticosterone; the simultaneous administration of
NMB-A prevented the effect of NMB. Neither NMB nor
NMB-A treatments induced significant changes in
adenohypophysis and adrenal weights, nor in the average
volume of zona glomerulosa and zona reticularis cells.
NMB-A administration lowered the volume of zona
fasciculata cells, an effect annulled by the concomitant
NMB administration. Our results suggest that NMB
specifically stimulates aldosterone secretion, and that
endogenous NMB or NMB-like peptides exert a tonic
stimulating action on the growth of zona fasciculata
cells.
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Citation
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