Publication: Is tendinitis an inflammatory disease initiated and driven
by pro-inflammatory cytokines such as interleukin 1ß?
| dc.contributor.author | Mobasheri, Ali | |
| dc.contributor.author | Shakibaei, M. | |
| dc.date.accessioned | 2018-06-21T13:38:57Z | |
| dc.date.available | 2018-06-21T13:38:57Z | |
| dc.date.issued | 2013 | |
| dc.description.abstract | Tendonitis and tendinitis are terms used to describe an inflamed and painful tendon. Tendinopathy, is a descriptive term for describing clinical conditions arising from tendon injury and overuse both within and around tendons. The aim of this mini-review is to explore the role of pro-inflammatory cytokines, particularly interleukin-1ß (IL-1ß) in tendon disorders. A number of investigators including our group have proposed that pro-inflammatory cytokines such as IL-1ß are initiators of tendinopathies, stimulating inflammation, apoptosis and extracellular matrix (ECM) degradation. This is one of the reasons why IL-1ß is frequently used in culture models of tendon inflammation to study the inflammatory and catabolic responses of tenocytes. However, some researchers oppose this view and suggest that although IL-1ß may play a role in rheumatoid arthritis (RA) and osteoarthritis (OA), the involvement of IL-1ß in the development of tendinopathy is questionable. This mini-review discusses the relevant papers published in this area and summarises the evidence for and against the involvement of pro-inflammatory cytokines such as IL1ß in tendonitis. Reaching a consensus will be important for the development and refinement of biomimetic models of tendon inflammation and the formulation of new therapeutic strategies for the treatment of tendon injuries. | es |
| dc.format | application/pdf | es |
| dc.format.extent | 10 | es |
| dc.identifier.citation | Histology and Histopathology, vol. 28, nº 8 (2013) | |
| dc.identifier.issn | 1699-5848 | |
| dc.identifier.issn | 0213-3911 | |
| dc.identifier.uri | http://hdl.handle.net/10201/59539 | |
| dc.language | eng | es |
| dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología | es |
| dc.rights | info:eu-repo/semantics/openAccess | es |
| dc.subject | Tendon | es |
| dc.subject | Tendonitis | es |
| dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
| dc.title | Is tendinitis an inflammatory disease initiated and driven by pro-inflammatory cytokines such as interleukin 1ß? | es |
| dc.type | info:eu-repo/semantics/article | es |
| dspace.entity.type | Publication | es |
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