Publication: Is tendinitis an inflammatory disease initiated and driven
by pro-inflammatory cytokines such as interleukin 1ß?
Authors
Mobasheri, Ali ; Shakibaei, M.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Tendonitis and tendinitis are terms used to
describe an inflamed and painful tendon. Tendinopathy,
is a descriptive term for describing clinical conditions
arising from tendon injury and overuse both within and
around tendons. The aim of this mini-review is to
explore the role of pro-inflammatory cytokines,
particularly interleukin-1ß (IL-1ß) in tendon disorders. A
number of investigators including our group have
proposed that pro-inflammatory cytokines such as IL-1ß
are initiators of tendinopathies, stimulating
inflammation, apoptosis and extracellular matrix (ECM)
degradation. This is one of the reasons why IL-1ß is
frequently used in culture models of tendon
inflammation to study the inflammatory and catabolic
responses of tenocytes. However, some researchers
oppose this view and suggest that although IL-1ß may
play a role in rheumatoid arthritis (RA) and osteoarthritis
(OA), the involvement of IL-1ß in the development of
tendinopathy is questionable. This mini-review discusses
the relevant papers published in this area and
summarises the evidence for and against the
involvement of pro-inflammatory cytokines such as IL1ß
in tendonitis. Reaching a consensus will be important
for the development and refinement of biomimetic
models of tendon inflammation and the formulation of
new therapeutic strategies for the treatment of tendon
injuries.
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Citation
Histology and Histopathology, vol. 28, nº 8 (2013)
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