Publication: No rapid and demarcating astroglial reaction to stab wounds in Agama and Gecko lizards and the caiman Paleosuchus - it is confined to birds and mammals
Authors
Lőrincz, Dávid ; Kálmán, Mihály
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-273
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info:eu-repo/semantics/article
Description
Abstract
y. The present study proves that the rapid and
demarcating astroglial reactions are confined to birds
and mammals. To understand the function of post-lesion
astroglial reaction, the phylogenetical aspects are also to
be investigated. Considering the regenerative
capabilities, reptiles represent an intermediate position
between the brain regeneration-permissive fishes and
amphibians and the almost non-permissive birds and
mammals. Damage is followed by a rapid astroglial
reaction in the mammalian and avian brain, which is
held as an impediment of regeneration. In other
vertebrates the reactions were usually observed
following long survival periods together with signs of
regeneration, therefore they can be regarded as
concomitant phenomena of regeneration. The present
study applies short post-lesion periods comparable to
those seen in mammals and birds for astroglial reactions.
Two species of lizards were used: gecko (leopard gecko,
Eublepharis macularius, Blyth, 1854) and agama
(bearded dragon, Pogona vitticeps, Ahl, 1926). The
gecko brain is rich in GFAP whereas the agama brain is
quite poor in this. Crocodilia, the closest extant relatives
of birds were represented in this study by Cuvier's dwarf
caiman (Paleosuchus palpebrosus, Cuvier, 1807). The
post-lesion astroglial reactions of crocodilians have
never been investigated. The injuries were stab wounds
in the telencephalon. The survival periods lasted 3, 7, 10
or 14 days. Immunoperoxidase reactions were performed
applying anti-GFAP, anti-vimentin and anti-nestin
reagents. No rapid and demarcating astroglial reaction
resembling that of mammalian or avian brains was
found. Alterations of the perivascular immunoreactivities of laminin and β-dystroglycan as indicators
of glio-vascular decoupling proved that the lesions were
effective on astroglia. The capability of rapid and
demarcating astroglial reaction seems to be confined to
mammals and birds and to appear by separate, parallel
evolution in them.
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Citation
Histology and Histopathology Vol. 35, nº12 (2020)
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