Publication: Cell adhesion molecules in human osteoblasts: structure and function
Authors
Bennett, J.H. ; Moffatt, S. ; Horton, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Osteoblasts and bone lining cells form a near
continuous layer covering the bone surface and
interactions between these cells and the organic matrix
of bone are important determinants of osteoblast
proliferation and differentiation. In addition, cells of the
osteoblast-lineage form functional cornrnunications with
each other, with the extra-cellular matrix and with
osteocytes through cytoplasmic processes extending
through canaliculi in the bone. Together, these cells form
a network of putative importance in the regulation of
skeletal homeostasis. Cell-cell and cell-matrix
interactions are mediated by members of severa1 families
of cell adhesion molecules, and knowledge of their
interactions will be of fundamental importance in
understanding the role of osteoblast in skeletal turnover .
Here, the expression pattern of members of the major
families of cell adhesion molecules by cells of the
osteoblast lineage is reviewed. Special emphasis has
been placed on human tissues. In addition, the possibility
that cells at progressive stages of the osteoblast lineage
have different profiles of cell adhesion molecule
expression is explored, and the putative significance of
cell-matrix interactions in human skeletal disease briefly
discussed.
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Citation
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