Publication: Arteria1 microvascularization and breast cancer colonization in bone
Authors
Yoneda, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Bone is one of the most preferential target
organs of cancer metastases. Breast, prostate and lung
cancers have a special predilection for colonization in
bone. In an animal model in which inoculation of cancer
cells into the left cardiac ventricle selectively develops
osteolytic bone metastases but rarely forms metastases
in non-bone organs, the pattern of breast cancer
colonization in bone was studied radiologically and
histologically. Colonization of cancer cells in bone
was found to initiate and develop along with or at the
terminal end of the major arteries running into bone. It
should, therefore, be re-recognized that the anatomical
vasculature still remains as a critica1 factor which
influences cancer colonization in bone in addition to
cellular and molecular properties of the bone microenvironment
and metastatic cancer cells.
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