Publication: Nuclear reprogramming and adult stem cell potential
Authors
Corti, S. ; Locatelli, F. ; Papadimitriou, D. ; Strazzer, S. ; Bonato, S. ; Comi, G.P.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Cell-based therapy may represent a new
strategy to treat a vast array of clinical disorders
including neurodegenerative diseases. Recent
observations indicate that adult somatic stem cells have
the capacity to contribute to the regeneration of different
tissues, suggesting that differentiative restrictions are not
completely irreversible and can be reprogrammed.
Cell fusion might account for some changed
phenotype of adult cells but it seems to be biologically
irrelevant for its extreme rarity. Other experimental
evidences are compatible with the hypothesis of wide
multipotency of well-defined stem cell populations, but
also with transdifferentiation and/or dedifferentiation.
Further studies on nuclear reprogramming mechanisms
are necessary to fulfil the promise for developing
autologous cellular therapies.
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