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The long non-coding RNA PANDAR regulates cell proliferation and epithelial-to-mesenchymal transition in glioma

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dc.contributor.authorGuo, Jianfeng
dc.contributor.authorXiao, Deyong
dc.contributor.authorLin, Zhijing
dc.contributor.authorSui, Chengzhi
dc.date.accessioned2023-03-13T09:34:40Z
dc.date.available2023-03-13T09:34:40Z
dc.date.issued2023
dc.description.abstractGlioma is one of the most aggressive intracranial tumors in the central nervous system. The long non-coding RNA P21-associated ncRNA DNA damage activated (PANDAR) has been reported to be an oncogene or tumor suppressor in several cancers. However, the prognostic value and biological function of PANDAR in glioma have not been described. Here, we report that expression of PANDAR is significantly upregulated in glioma tissues and cell lines. PANDAR expression was correlated with tumor size (p=0.044) and World Health Organization (WHO) grades (p=0.005), as shown by chi-squared test. Moreover, significant upregulation of PANDAR was found to correlate with poor prognosis in glioma, as shown using Kaplan-Meier method and Cox multivariate survival analysis. Furthermore, PANDAR knockdown suppressed cell proliferation, G1/S transition, migration and invasion, and promoted apoptosis in glioma cell lines (U251 and U87). PANDAR knockdown decreased expression of CDK4, Bcl-2, N-cadherin and Vimentin, but increased E-cadherin expression in glioma cells. In conclusion, our data suggest PANDAR as a potential prognostic biomarker and therapeutic candidate for glioma.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationHistology and Histopathology Vol. 38, nº2 (2023)
dc.identifier.doihttps://doi.org/ 10.14670/HH-18-511
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/129326
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGliomaes
dc.subjectPANDARes
dc.subjectProliferationes
dc.subjectEMTes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleThe long non-coding RNA PANDAR regulates cell proliferation and epithelial-to-mesenchymal transition in gliomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nº2 (2023)