Publication: The long non-coding RNA PANDAR regulates cell proliferation and epithelial-to-mesenchymal transition in glioma
Authors
Guo, Jianfeng ; Xiao, Deyong ; Lin, Zhijing ; Sui, Chengzhi
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/ 10.14670/HH-18-511
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info:eu-repo/semantics/article
Description
Abstract
Glioma is one of the most aggressive
intracranial tumors in the central nervous system. The
long non-coding RNA P21-associated ncRNA DNA
damage activated (PANDAR) has been reported to be an
oncogene or tumor suppressor in several cancers.
However, the prognostic value and biological function of
PANDAR in glioma have not been described. Here, we
report that expression of PANDAR is significantly upregulated in glioma tissues and cell lines. PANDAR
expression was correlated with tumor size (p=0.044) and
World Health Organization (WHO) grades (p=0.005), as
shown by chi-squared test. Moreover, significant
upregulation of PANDAR was found to correlate with
poor prognosis in glioma, as shown using Kaplan-Meier
method and Cox multivariate survival analysis.
Furthermore, PANDAR knockdown suppressed cell
proliferation, G1/S transition, migration and invasion,
and promoted apoptosis in glioma cell lines (U251 and
U87). PANDAR knockdown decreased expression of
CDK4, Bcl-2, N-cadherin and Vimentin, but increased
E-cadherin expression in glioma cells. In conclusion, our
data suggest PANDAR as a potential prognostic
biomarker and therapeutic candidate for glioma.
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Citation
Histology and Histopathology Vol. 38, nº2 (2023)
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