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Serum proteome of dogs at subclinical and clinical onset of canine leishmaniosis

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dc.contributor.authorFranco-Martinez, Lorena
dc.contributor.authorVillar, Margarita
dc.contributor.authorTvarijonaviciute, Asta
dc.contributor.authorEscribano, Damian
dc.contributor.authorBernal, Luis J.
dc.contributor.authorCeron, Jose J.
dc.contributor.authorThomas, Maria del Carmen
dc.contributor.authorMateos-Hernandez, Lourdes
dc.contributor.authorTecles, Fernando
dc.contributor.authorDe la Fuente, Jose
dc.contributor.authorLópez, Manuel C.
dc.contributor.authorMartinez-Subiela, Silvia
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2024-02-06T07:59:03Z
dc.date.available2024-02-06T07:59:03Z
dc.date.issued2019
dc.description.abstractThe objective of this study was to identify changes in serum proteome in dogs that may occur after an experimental infection at subclinical and clinical stages of canine leishmaniosis (CanL). For this purpose, canine pre- and post-infection with Leishmania infantum serum proteomes in the same dogs were analysed by a high-throughput label-based quantitative LC-MS/MS proteomic approach. A total of 169 proteins were identified, and 74 of them including complement C8 alpha chain, adiponectin, transferrin, sphingomyelin phosphodiesterase acid-like 3A and immunoglobulins showed different modulation between the different stages of CanL. These proteins could be considered as potential serum biomarkers of early diagnostic or disease progression in CanL. Additionally, biological pathways modulated during CanL such as blood coagulation or gonadotropin-releasing hormone receptor were revealed, which could help to understand the pathological mechanisms of the disease.es
dc.embargo.terms1-ene-2999
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationTransboundary and Emerging Diseases 67(1): 318-327 (2020)
dc.identifier.doihttps://doi.org/10.1111/tbed.13354
dc.identifier.urihttp://hdl.handle.net/10201/138689
dc.languageenges
dc.publisherWiley-VCHes
dc.relationRamón y Cajal Programa Estatal I+D+I Research Plan of University of Castilla- La Mancha Program for Research Groups of Excellence Seneca Foundation Predoctoral grant FPU, University of Murciaes
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1111/tbed.13354es
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBiomarkerses
dc.subjectDog diseases,es
dc.subjectLeishmania,es
dc.subjectproteomicses
dc.subjectSWATH‐MSes
dc.subject.otherCDU::6 - Ciencias aplicadas::63 - Agricultura. Silvicultura. Zootecnia. Caza. Pesca::636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticoses
dc.titleSerum proteome of dogs at subclinical and clinical onset of canine leishmaniosises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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