Publication: Serum proteome of dogs at subclinical and clinical onset of canine leishmaniosis
Loading...
Date
2019
Authors
Franco-Martinez, Lorena ; Villar, Margarita ; Tvarijonaviciute, Asta ; Escribano, Damian ; Bernal, Luis J. ; Ceron, Jose J. ; Thomas, Maria del Carmen ; Mateos-Hernandez, Lourdes ; Tecles, Fernando ; De la Fuente, Jose ; López, Manuel C. ; Martinez-Subiela, Silvia
item.page.secondaryauthor
item.page.director
Publisher
Wiley-VCH
publication.page.editor
publication.page.department
DOI
https://doi.org/10.1111/tbed.13354
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The objective of this study was to identify changes in serum proteome in dogs that may occur after an experimental infection at subclinical and clinical stages of canine leishmaniosis (CanL). For this purpose, canine pre- and post-infection with Leishmania infantum serum proteomes in the same dogs were analysed by a high-throughput label-based quantitative LC-MS/MS proteomic approach. A total of 169 proteins were identified, and 74 of them including complement C8 alpha chain, adiponectin, transferrin, sphingomyelin phosphodiesterase acid-like 3A and immunoglobulins showed different modulation between the different stages of CanL. These proteins could be considered as potential serum biomarkers of early diagnostic or disease progression in CanL. Additionally, biological pathways modulated during CanL such as blood coagulation or gonadotropin-releasing hormone receptor were revealed, which could help to understand the pathological mechanisms of the disease.
publication.page.subject
Citation
Transboundary and Emerging Diseases 67(1): 318-327 (2020)
item.page.embargo
1-ene-2999
Collections
Ir a Estadísticas
Sin licencia Creative Commons.