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Protective effects of the pericellular matrix of chondrocyte on articular cartilage against the development of osteoarthritis

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dc.contributor.authorLiu, Chenlu
dc.contributor.authorWang, Beiyu
dc.contributor.authorXiao, Li
dc.contributor.authorLi, Yefu
dc.contributor.authorXu, Lin
dc.contributor.authorZhao, Zhihe
dc.contributor.authorZhang, Lin
dc.date.accessioned2022-05-11T09:28:24Z
dc.date.available2022-05-11T09:28:24Z
dc.date.issued2018
dc.description.abstractUnderstanding the pathogenesis of osteoarthritis (OA) provides invaluable information in the search of therapeutic targets for the development of disease-modifying OA drugs. Emerging results from investigations demonstrate that the pericellular matrix of chondrocytes plays important roles in protecting articular cartilages from being degraded. Thus, maintaining the structural integrity of the pericellular matrix may be an effective approach to prevent the development of osteoarthritic joints. In this review article, we discuss the consequences of lacking one or more components of the pericellular matrix, and biological effects of the destruction of the pericellular matrix in the development of OA. We believe that more attention should be directed towards the pericellular matrix for the identification of novel biomarkers and therapeutic targets for the prevention and treatment of OA.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.citationHistology and Histopathology, Vol.33, nÂş8, (2018)
dc.identifier.doiDOI: 10.14670/HH-11-967
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/119812
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectOsteoarthritises
dc.subjectArticular cartilagees
dc.subjectChondrones
dc.subjectPericellular matrixes
dc.subjectAnimal modeles
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleProtective effects of the pericellular matrix of chondrocyte on articular cartilage against the development of osteoarthritises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.33, nÂş8 (2018)