Publication:
Protective effects of the pericellular matrix of chondrocyte on articular cartilage against the development of osteoarthritis

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Liu-33-757-764-2018.pdf(234.06 KB)
Date
2018
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Authors
Liu, Chenlu ; Wang, Beiyu ; Xiao, Li ; Li, Yefu ; Xu, Lin ; Zhao, Zhihe ; Zhang, Lin
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Publisher
Universidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­a
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DOI
DOI: 10.14670/HH-11-967
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info:eu-repo/semantics/article
Description
Abstract
Understanding the pathogenesis of osteoarthritis (OA) provides invaluable information in the search of therapeutic targets for the development of disease-modifying OA drugs. Emerging results from investigations demonstrate that the pericellular matrix of chondrocytes plays important roles in protecting articular cartilages from being degraded. Thus, maintaining the structural integrity of the pericellular matrix may be an effective approach to prevent the development of osteoarthritic joints. In this review article, we discuss the consequences of lacking one or more components of the pericellular matrix, and biological effects of the destruction of the pericellular matrix in the development of OA. We believe that more attention should be directed towards the pericellular matrix for the identification of novel biomarkers and therapeutic targets for the prevention and treatment of OA.
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Osteoarthritis , Articular cartilage , Chondron , Pericellular matrix , Animal model
Citation
Histology and Histopathology, Vol.33, nÂş8, (2018)
URI
http://hdl.handle.net/10201/119812
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Histology and histopathology Vol.33, nÂş8 (2018)
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