Pannexin-1 mediates large pore formation and interleukin-1ß release by the ATP-gated P2X7 receptor

Pelegrin, Pablo; Surprenant, Annmarie

Publication:
Pannexin-1 mediates large pore formation and interleukin-1ß release by the ATP-gated P2X7 receptor

dc.contributor.author	Pelegrin, Pablo
dc.contributor.author	Surprenant, Annmarie
dc.contributor.department	Bioquímica y Biología Molecular B e Inmunología
dc.date.accessioned	2024-01-24T17:22:04Z
dc.date.available	2024-01-24T17:22:04Z
dc.date.issued	2006
dc.description	©2006. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the, Accepted, version of a Published Work that appeared in final form in The EMBO Journal. To access the final edited and published work see https://doi.org/10.1038/sj.emboj.7601378	es
dc.description.abstract	P2X(7) receptors are ATP-gated cation channels; their activation in macrophage also leads to rapid opening of a membrane pore permeable to dyes such as ethidium, and to release of the pro-inflammatory cytokine, interleukin-1beta (IL-1beta). It has not been known what this dye-uptake path is, or whether it is involved in downstream signalling to IL-1beta release. Here, we identify pannexin-1, a recently described mammalian protein that functions as a hemichannel when ectopically expressed, as this dye-uptake pathway and show that signalling through pannexin-1 is required for processing of caspase-1 and release of mature IL-1beta induced by P2X(7) receptor activation.	es
dc.format	application/pdf	es
dc.format.extent	45	es
dc.identifier.citation	EMBO Journal, volumen 25, nº 21, año 2006, páginas: 5071-5082.
dc.identifier.doi	10.1038/sj.emboj.7601378
dc.identifier.issn	0261-4189
dc.identifier.issn	1460-2075
dc.identifier.uri	http://hdl.handle.net/10201/137719
dc.language	eng	es
dc.relation	Wellcome Trust y AstraZeneca Charnwood.	es
dc.relation.publisherversion	https://www.embopress.org/doi/full/10.1038/sj.emboj.7601378?pubCode=cgi	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Citocinas	es
dc.subject	Canal iónico	es
dc.subject	Hemicanal	es
dc.subject	Inflamasoma	es
dc.subject	Receptor purinérgico	es
dc.subject.other	CDU::6 - Ciencias aplicadas	es
dc.title	Pannexin-1 mediates large pore formation and interleukin-1ß release by the ATP-gated P2X7 receptor	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es