Publication: Pannexin-1 mediates large pore formation and interleukin-1ß release by the ATP-gated P2X7 receptor
Authors
Pelegrin, Pablo ; Surprenant, Annmarie
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DOI
10.1038/sj.emboj.7601378
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info:eu-repo/semantics/article
Description
©2006. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This document is the, Accepted, version of a Published Work that appeared in final form in The EMBO Journal. To access the final edited and published work see https://doi.org/10.1038/sj.emboj.7601378
Abstract
P2X(7) receptors are ATP-gated cation channels; their activation in macrophage also leads to rapid opening of a membrane pore permeable to dyes such as ethidium, and to release of the pro-inflammatory cytokine, interleukin-1beta (IL-1beta). It has not been known what this dye-uptake path is, or whether it is involved in downstream signalling to IL-1beta release. Here, we identify pannexin-1, a recently described mammalian protein that functions as a hemichannel when ectopically expressed, as this dye-uptake pathway and show that signalling through pannexin-1 is required for processing of caspase-1 and release of mature IL-1beta induced by P2X(7) receptor activation.
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Citation
EMBO Journal, volumen 25, nº 21, año 2006, páginas: 5071-5082.
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