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Human resident CD34+ stromal cells/telocytes have progenitor capacity and are a source of αSMA+ cells during repair

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dc.contributor.authorDíaz-Flores, L.
dc.contributor.authorGutiérrez, R.
dc.contributor.authorGarcía, M.P.
dc.contributor.authorGonzález, M.
dc.contributor.authorSáez, F.J.
dc.contributor.authorAparicio, F.
dc.contributor.authorDíaz-Flores Jr., L.
dc.contributor.authorMadrid Cuevas, Juan Francisco
dc.date.accessioned2020-04-22T16:41:16Z
dc.date.available2020-04-22T16:41:16Z
dc.date.issued2015
dc.description.abstractWe studied the progenitor capacity of human resident CD34+ stromal cells/telocytes (SC/TCs) in the enteric wall affected by inflammatory/repair processes (appendicitis, diverticulitis of large bowel and Crohn’s disease of the terminal ileum) at different stages of evolution (inflammatory, proliferative and remodelling). In these conditions, CD34+ SC/TCs are activated, showing changes, which include the following overlapping events: 1) separation from adjacent structures (e.g., from vascular walls) and location in oedematous spaces, 2) morphological modifications (in cell shape and size) with presence of transitional cell forms between quiescent and activated CD34+ SC/TCs, 3) rapid proliferation and 4) loss of CD34 expression and gain of αSMA expression. These events mainly occur in the inflammatory and proliferative stages. During the loss of CD34 expression, the following findings are observed: a) irregular cell labelling intensity for anti-CD34, b) co-localization of CD34 and actin, c) concurrent irregular labelling intensity for αSMA and d) αSMA expression in all stromal cells, with total loss of CD34 expression. While CD34 expression was conserved, a high proliferative capacity (Ki-67 expression) was observed and vice versa. In the segments of the ileum affected by Crohn’s disease, the stromal cells around fissures were αSMA+ and, in the transitional zones with normal enteric wall, activated CD34+ SC/TCs were observed. In conclusion, human resident CD34+ SC/TCs in the enteric wall have progenitor capacity and are activated with or without differentiation into αSMA+ stromal cells during inflammatory/repair processes.es
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dc.format.extent13es
dc.identifier.citationHistology and Histopathology, Vol. 30, n.º 5 (2015)
dc.identifier.doihttps://doi.org/10.14670/HH-30.615
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/90301
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCD34+ stromal cellses
dc.subjectTelocyteses
dc.subjectαSMA+ stromal cellses
dc.subjectBowees
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleHuman resident CD34+ stromal cells/telocytes have progenitor capacity and are a source of αSMA+ cells during repaires
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication773c85c2-1260-4a4d-9543-f5a615648d71
relation.isAuthorOfPublication.latestForDiscovery773c85c2-1260-4a4d-9543-f5a615648d71
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Histology and histopathology Vol.30, nº5 (2015)