Publication: Pathological diagnosis, differential diagnosis and origin investigation of easily misdiagnosed adult gastric duplication cysts
Authors
Liu, Fangfang ; Zhao, Huimin
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-417
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info:eu-repo/semantics/article
Description
Abstract
Objectives. To study diagnosis, differential
diagnosis, and origin of easily misdiagnosed adult
gastric duplication cysts.
Methods. Six cases with GDCs were studied using
immunohistochemical methods to research the
expression of tumor markers.
Results. Most GDCs were located in the abdominal
cavity outside the digestive organs. The cyst wall tissues
included a repetition of the full-thickness structure of the
stomach wall that was lined by a variety of different
epithelia. The expression of CK7 was positive in all
epithelia (6/6), while CK7 expression was positive in
cardia glands in 5/5 and positive in fundus glands in 1/5.
CK 20 was 100% (4/4) positively expressed in the SCE,
100% (3/3) negative in the CCE, and in the SE. It was
also expressed positively 100% (5/5) in fundus glands
and 80% (4/5) in cardia glands. Both CK7 and CK20
were negatively expressed in the pyloric glands in case
3. The expression of MUC1 was positive in all epithelia
and glands, whereas MUC2 expression was negative.
MUC5AC was expressed differently in epithelia and
glands.
Conclusions. GDCs can originate from the antrum or
the fundus of the stomach. Tumor markers can help
diagnosis and differential diagnosis. This study may help
to improve clinical precision treatment.
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Citation
Histology and Histopathology Vol. 37, nº2 (2022)
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