Publication: The sorting and trafficking of lysosomal proteins
Authors
Ni, X. ; Canuel, Maryssa ; Morales, Carlos R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
For a long time lysosomes were considered
terminal organelles involved in the degradation of
different substrates. However, this view is rapidly
changing by evidence demonstrating that these
organelles and their content display specialized functions
in addition to the degradation of substances. Many
lysosomal proteins have been implicated in specialized
cellular functions and disorders such as antigen
processing, targeting of surfactant proteins, and most
lysosomal storage disorders. To date, about fifty
lysosomal hydrolases have been identified, and the
majority of them are targeted to the lysosomes via the
mannose-6-phosphate receptor (M6P-Rc). However,
recent studies on the intracellular trafficking of the nonenzymic
lysosomal proteins prosaposin and GM2
activator (GM2AP) demonstrated that they use an
alternative receptor termed “sortilin”. Existing evidence
suggests that some hydrolases traffic to the lysosomes in
a mannose 6-phophate-indepentend manner. The
possibility that sortilin is implicated in the targeting of
some soluble hydrolases, as well as the consequences of
this process, is addressed in the present review.
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