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Insights into iron and nuclear factor-kappa B (NF-κB) involvement in chronic inflammatory processes in peritoneal endometriosis

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dc.contributor.authorDefrère, Sylvie
dc.contributor.authorGonzález-Ramos, Reinaldo
dc.contributor.authorLousse, Jean-Christophe
dc.contributor.authorColette, Sébastien
dc.contributor.authorDonnez, Olivier
dc.contributor.authorDonnez, Jacques
dc.contributor.authorVan Langendonckt, Anne
dc.date.accessioned2016-05-05T15:14:14Z
dc.date.available2016-05-05T15:14:14Z
dc.date.issued2011
dc.description.abstractEndometriosis is a chronic pelvic inflammatory process. Local inflammation is known to play a role in pain and infertility associated with the disease, and may be extensively involved in molecular and cellular processes leading to endometriosis development. In this review, we focus on two inflammatory mediators clearly implicated in the pathogenesis of endometriosis, iron and NF-κB, and their potential association. Iron is essential for all living organisms, but excess iron results in toxicity and is linked to pathological disorders. In endometriosis patients, iron overload has been demonstrated in the different compartments of the peritoneal cavity (peritoneal fluid, endometriotic lesions, peritoneum and macrophages). This iron overload affects numerous mechanisms involved in endometriosis development. Moreover, iron can generate free radical species able to react with a wide range of cellular constituents, inducing cellular damage. Overproduction of reactive oxygen species also impairs cellular function by altering gene expression via regulation of redox-sensitive transcription factors such as NF-κB, which is clearly implicated in endometriosis. Indeed, NF-κB is activated in endometriotic lesions and peritoneal macrophages of endometriosis patients, which stimulates synthesis of proinflammatory cytokines, generating a positive feedback loop in the NF-κB pathway. NF-κB-mediated gene transcription promotes a variety of processes, including endometriotic lesion establishment, maintenance and development. In conclusion, iron and NF-κB appear to be linked and both are clearly involved in endometriosis development, making these pathways an attractive target for future treatment and prevention of this disease.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/49563
dc.languageenges
dc.publisherMurcia: F. Hernández y J.F. Madrid, Universidad de Murcia, Departamento de Biología Celular e Histologíaes
dc.relation.ispartofHistology and histopathology, Vol. 26, nº 8 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectEndometriosises
dc.subjectInflammationes
dc.subject.other618 - Ginecología. Obstetriciaes
dc.titleInsights into iron and nuclear factor-kappa B (NF-κB) involvement in chronic inflammatory processes in peritoneal endometriosises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26, nº8 (2011)