Publication: Insights into iron and nuclear
factor-kappa B (NF-κB) involvement in chronic
inflammatory processes in peritoneal endometriosis
Authors
Defrère, Sylvie ; González-Ramos, Reinaldo ; Lousse, Jean-Christophe ; Colette, Sébastien ; Donnez, Olivier ; Donnez, Jacques ; Van Langendonckt, Anne
item.page.secondaryauthor
item.page.director
Publisher
Murcia: F. Hernández y J.F. Madrid, Universidad de Murcia, Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Endometriosis is a chronic pelvic
inflammatory process. Local inflammation is known to
play a role in pain and infertility associated with the
disease, and may be extensively involved in molecular
and cellular processes leading to endometriosis
development. In this review, we focus on two
inflammatory mediators clearly implicated in the
pathogenesis of endometriosis, iron and NF-κB, and
their potential association. Iron is essential for all living
organisms, but excess iron results in toxicity and is
linked to pathological disorders. In endometriosis
patients, iron overload has been demonstrated in the
different compartments of the peritoneal cavity
(peritoneal fluid, endometriotic lesions, peritoneum and
macrophages). This iron overload affects numerous
mechanisms involved in endometriosis development.
Moreover, iron can generate free radical species able to
react with a wide range of cellular constituents, inducing
cellular damage. Overproduction of reactive oxygen
species also impairs cellular function by altering gene
expression via regulation of redox-sensitive transcription
factors such as NF-κB, which is clearly implicated in
endometriosis. Indeed, NF-κB is activated in
endometriotic lesions and peritoneal macrophages of
endometriosis patients, which stimulates synthesis of
proinflammatory cytokines, generating a positive
feedback loop in the NF-κB pathway. NF-κB-mediated
gene transcription promotes a variety of processes,
including endometriotic lesion establishment,
maintenance and development. In conclusion, iron and NF-κB appear to be linked and both are clearly involved
in endometriosis development, making these pathways
an attractive target for future treatment and prevention of
this disease.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.