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Cytoplasmic inclusions of TDP-43 in neurodegenerative diseases: A potential role for caspases

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Cytoplasmic inclusions of TDP43 in neurodegenerative Cytoplasmic inclusions of TDP43 in neurodegenerative.pdf(3.05 MB)
Date
2009
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Authors
Rohn, Troy T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
TAR DNA-binding protein-43 (TDP-43) proteinopathies are classified based upon the extent of modified TDP-43 inclusions and include a growing number of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with ubiquitin immunoreactive, tau negative inclusions (FTLD-U) and FTLD with motor neuron disease (FTLD-MND). In addition, TDP-43 inclusions have also been identified in a number of other neurodegenerative disorders including Alzheimer’s disease, corticobasal degeneration, Lewy body related diseases and Pick’s disease. Current understanding suggests that in these diseases, TDP-43 is relocated from the nucleus to the cytoplasm and sequestered into inclusions that contain modified TDP-43. Major modifications of TDP-43 have been identified as being hyperphosphorylation and proteolytic cleavage by caspases. In this review a summary of the major findings regarding the proteolytic modification of TDP-43 will be discussed as well as potential toxic-gain mechanisms these fragments may cause including cytoskeletal disruptions.
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Alzheimer’s disease , Hirano Bodies
Citation
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http://hdl.handle.net/10201/36060
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Histology and histopathology Vol.24, nº8 (2009)
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