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Expression of receptor for hyaluronan-mediated motility (RHAMM) in ossifying fibromas

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dc.contributor.authorHatano, Hiroko
dc.contributor.authorOgawa, Ikuko
dc.contributor.authorShigeishi, Hideo
dc.contributor.authorKudo, Yasusei
dc.contributor.authorOhta, Kouji
dc.contributor.authorHigashikawa, Koichiro
dc.contributor.authorTakechi, Masaaki
dc.contributor.authorTakata, Takashi
dc.contributor.authorKamata, Nobuyuki
dc.date.accessioned2018-03-09T16:35:24Z
dc.date.available2018-03-09T16:35:24Z
dc.date.issued2013
dc.description.abstractFibro-osseous lesions of the jaw are poorly understood because of a significant overlap of clinical, radiological and histological features among the various types, though they present distinct patterns of disease progression. An ossifying fibroma is associated with significant cosmetic and functional disturbances, as it shows expansive proliferation. Thus, it is important to establish a specific marker, as well as clearly elucidate its etiology for diagnosis and proper treatment. We previously established immortalized cell lines from human ossifying fibromas of the jaw and found that they highly expressed the receptor for hyaluronan (HA)-mediated motility (RHAMM). In this study, we examined the expression of RHAMM mRNA in 65 fibro-osseous lesions, including ossifying fibroma, fibrous dysplasia and osseous dysplasia, as well as 5 normal jaws, using real-time RT-PCR and immunohistochemistry assays. RHAMM mRNA and protein expression were significantly elevated in the ossifying fibroma specimens. These results suggest that detection of upregulated RHAMM expression in an ossifying fibroma assists with differential diagnosis and has a key role in elucidation of its pathophysiology.es
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dc.format.extent8es
dc.identifier.citationHistology and histopathology, Vol. 28, n.º 4 (2013)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/57129
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectFibro-osseous lesiones
dc.subjectOssifyinges
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleExpression of receptor for hyaluronan-mediated motility (RHAMM) in ossifying fibromases
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.28, nº 4 (2013)