Publication: Expression of receptor for hyaluronan-mediated motility (RHAMM) in ossifying fibromas
Authors
Hatano, Hiroko ; Ogawa, Ikuko ; Shigeishi, Hideo ; Kudo, Yasusei ; Ohta, Kouji ; Higashikawa, Koichiro ; Takechi, Masaaki ; Takata, Takashi ; Kamata, Nobuyuki
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Fibro-osseous lesions of the jaw are poorly
understood because of a significant overlap of clinical,
radiological and histological features among the various
types, though they present distinct patterns of disease
progression. An ossifying fibroma is associated with
significant cosmetic and functional disturbances, as it
shows expansive proliferation. Thus, it is important to
establish a specific marker, as well as clearly elucidate
its etiology for diagnosis and proper treatment.
We previously established immortalized cell lines
from human ossifying fibromas of the jaw and found
that they highly expressed the receptor for hyaluronan
(HA)-mediated motility (RHAMM). In this study, we
examined the expression of RHAMM mRNA in 65
fibro-osseous lesions, including ossifying fibroma,
fibrous dysplasia and osseous dysplasia, as well as 5
normal jaws, using real-time RT-PCR and immunohistochemistry
assays. RHAMM mRNA and protein
expression were significantly elevated in the ossifying
fibroma specimens.
These results suggest that detection of upregulated
RHAMM expression in an ossifying fibroma assists with
differential diagnosis and has a key role in elucidation of
its pathophysiology.
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Citation
Histology and histopathology, Vol. 28, n.º 4 (2013)
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