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Chemokine CCL14 affected the clinical outcome and correlated with immune infiltrates in thyroid carcinoma

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dc.contributor.authorZhang, Mi mi
dc.contributor.authorZhao, Yan dong
dc.contributor.authorLi, Qiang
dc.contributor.authorHe, Yue jun
dc.date.accessioned2023-05-25T08:39:33Z
dc.date.available2023-05-25T08:39:33Z
dc.date.issued2023
dc.description.abstractBackground. As an important member of the chemokines, CCL14 plays a vital role in cancer progression. However, the role of CCL14 in THCA has not been investigated. This study aimed to reveal the clinical significance of CCL14 in THCA. Material and Methods. This study evaluated the expression and prognostic value of CCL14 in THCA. Also, the correlation between CCL14 and immune infiltrates was assessed. Enrichment analysis was finally performed to predict CCL14-associated pathways involved in THCA. Results. The mRNA and protein expressions of CCL14 in THCA tissues were down-regulated compared with normal tissues. CCL14 high expression predicted favorable DFI and PFI but did not influence the DSS and OS. Further, CCL14 showed a good prediction performance on the PFI of patients. Enrichment analysis found that CCL14 was negatively correlated with migration-related pathways such as Notch signaling, ECM-receptor interaction, and cell adhesion molecules. Further, we found that CCL14 was negatively related to immune infiltrates and their gene markers. A negative relationship was also observed between CCL14 and immune checkpoint genes. These results implied the potential effect of CCL14 on the immune response and immune therapy in THCA. Conclusions. CCL14 high expression prolonged the DFI and PFI of THCA patients. It was negatively correlated with the migration-related pathways, suggesting that CCL14 might participate in the recurrence of THCA. Further, CCL14 was also shown to be important in immune response and immune therapy in THCA.es
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dc.format.extent13es
dc.identifier.citationHistology and Histopathology Vol. 38, nº6 (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-548
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/131446
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCCL14es
dc.subjectChemokinees
dc.subjectThyroid carcinomaes
dc.subjectExpressiones
dc.subjectSurvivales
dc.subjectPathwayes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleChemokine CCL14 affected the clinical outcome and correlated with immune infiltrates in thyroid carcinomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nº6 (2023)