Publication: a-Methylacyl coenzyme A racemase is highly expressed in the intestinal-type adenocarcinoma and high-grade dysplasia lesions of the stomach
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Date
2008
Authors
Huang, Wenbin ; Zhao, Jianhua ; Li, Li ; Huang, Yue ; Yang, Xiaobin ; Wang, Jinsong ; Zhang, Tonghai
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
To study a-Methylacyl coenzyme A
racemase (AMACR) expression in gastric intestinal-type
adenocarcinoma and its precursors, we performed an
immunohistochemical assay (using an avidin-biotinperoxidase
complex method) on 106 paraffin-embedded
gastric mucosal biopsy samples and 25 gastrectomy
samples (37 negative for dysplasia; 30 indefinite for
dysplasia; 22 low-grade dysplasia; 25 high-grade
dysplasia; and 34 invasive intestinal adenocarcinoma).
The results showed that AMACR staining was uniformly
negative in the groups negative for dysplasia and
indefinite for dysplasia. Only 1 of 22 (4.5%) low-grade
dysplasia showed weak staining for AMACR. In the
groups of high-grade dysplasia and invasive intestinaltype
adenocarcinoma, however, 19 of 25 (76%) and 18
of 34 (52.9%) were positive for AMACR respectively.
Expression of AMACR was not correlated with location,
H. Pylori infection or intestinal metaplasia. These results
suggested that AMACR may play a role in the
intermediate stage of gastric carcinogenesis. The high
level expression of AMACR in high-grade dysplasia and
carcinoma suggests that it may be a useful biomarker in
distinguishing high-grade dysplasia and carcinoma from
low-grade dysplasia.
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