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Regulation of inflammatory cytokines for spinal cord injury recovery

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dc.contributor.authorLin, Sen
dc.contributor.authorXu, Chang
dc.contributor.authorLin, Jiaquan
dc.contributor.authorHu, Hengshuo
dc.contributor.authorZhang, Chuanjie
dc.contributor.authorMei, Xifan
dc.date.accessioned2022-12-22T11:51:24Z
dc.date.available2022-12-22T11:51:24Z
dc.date.issued2021
dc.description.abstractSpinal cord injury (SCI) is one of the most destructive traumatic diseases in human beings. The balance of inflammation in the microenvironment is crucial to the repair process of spinal cord injury. Inflammatory cytokines are direct mediators of local lesion inflammation and affect the prognosis of spinal cord injury to varying degrees. In spinal cord injury models, some inflammatory cytokines are beneficial for spinal cord repair, while others are harmful. A large number of animal studies have shown that local targeted administration can effectively regulate the secretion and delivery of inflammatory cytokines and promote the repair of spinal cord injury. In addition, many clinical studies have shown that drugs can promote the repair of spinal cord injury by regulating the content of inflammatory cytokines. However, topical administration affects only a small portion of inflammatory cytokines. In addition, different individuals have different inflammatory cytokine profiles during spinal cord injury. Therefore, future research should aim to develop a personalized local delivery therapeutic cocktail strategy to effectively and accurately regulate inflammation and obtain substantial functional recovery from spinal cord injuryes
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.citationHistology and Histopathology Vol. 36, nº2 (2021)
dc.identifier.doihttps://doi.org/10.14670/HH-18-262
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/126748
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSpinal cord injuryes
dc.subjectNeuroinflammationes
dc.subjectInflammatory cytokineses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleRegulation of inflammatory cytokines for spinal cord injury recoveryes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36, nº2 (2021)