Publication: Regulation of inflammatory cytokines for spinal cord injury recovery
Authors
Lin, Sen ; Xu, Chang ; Lin, Jiaquan ; Hu, Hengshuo ; Zhang, Chuanjie ; Mei, Xifan
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-262
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info:eu-repo/semantics/article
Description
Abstract
Spinal cord injury (SCI) is one of the most
destructive traumatic diseases in human beings. The
balance of inflammation in the microenvironment is
crucial to the repair process of spinal cord injury.
Inflammatory cytokines are direct mediators of local
lesion inflammation and affect the prognosis of spinal
cord injury to varying degrees. In spinal cord injury
models, some inflammatory cytokines are beneficial for
spinal cord repair, while others are harmful. A large
number of animal studies have shown that local targeted
administration can effectively regulate the secretion and
delivery of inflammatory cytokines and promote the
repair of spinal cord injury. In addition, many clinical
studies have shown that drugs can promote the repair of
spinal cord injury by regulating the content of
inflammatory cytokines. However, topical
administration affects only a small portion of
inflammatory cytokines. In addition, different
individuals have different inflammatory cytokine
profiles during spinal cord injury. Therefore, future
research should aim to develop a personalized local
delivery therapeutic cocktail strategy to effectively and
accurately regulate inflammation and obtain substantial
functional recovery from spinal cord injury
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Citation
Histology and Histopathology Vol. 36, nº2 (2021)
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