hu-PBL-SCID mice: an in vivo model of Epstein-Barr virus-dependent lymphoproliferative disease

Publication:
hu-PBL-SCID mice: an in vivo model of Epstein-Barr virus-dependent lymphoproliferative disease

dc.contributor.author	Fuzzati-Armentero, M.T.	es
dc.contributor.author	Duchosal, M.A.	es
dc.date.accessioned	2011-02-22T10:58:04Z
dc.date.available	2011-02-22T10:58:04Z
dc.date.issued	1998
dc.description.abstract	The Epstein-Barr virus (EBV) exists in most huni:tns as a lifelong latent infection established in host B cells after a primary viral encounter. In immunosuppressed intlivitluals, such as post-transpl~rnt patients, the presence of EBV-infected B cells may lcad to Iq'niplloproliferative disease. Injection of human peripheral blood lymphocytes from EBV-positive clonors into mice wit h severe combined immunodeficiency induces human lymphoproliferative disease i n the recipient closely resembling that of human posttransplant patients. This xenochimeric human-mouse model is increasingly being used to elucidwrc the mcchnnisms of EBV-specific lymphomagenesis and to assess novel therapeutic approaches.	es
dc.format	application/pdf	es
dc.format.extent	14	es
dc.identifier.issn	0213-3911	es
dc.identifier.uri	http://hdl.handle.net/10201/19033
dc.language	eng	es
dc.publisher	Murcia : F. Hernández	es
dc.relation.ispartof	Histology and histopathology	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.subject	Epstein-Barr virus	es
dc.subject	Lymphoproliferative disease	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina	es
dc.title	hu-PBL-SCID mice: an in vivo model of Epstein-Barr virus-dependent lymphoproliferative disease	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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