Publication: hu-PBL-SCID mice: an in vivo model of Epstein-Barr virus-dependent lymphoproliferative disease
Authors
Fuzzati-Armentero, M.T. ; Duchosal, M.A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The Epstein-Barr virus (EBV) exists in most
huni:tns as a lifelong latent infection established in host
B cells after a primary viral encounter. In immunosuppressed
intlivitluals, such as post-transpl~rnt patients,
the presence of EBV-infected B cells may lcad to
Iq'niplloproliferative disease. Injection of human
peripheral blood lymphocytes from EBV-positive clonors
into mice wit h severe combined immunodeficiency
induces human lymphoproliferative disease i n the
recipient closely resembling that of human posttransplant
patients. This xenochimeric human-mouse
model is increasingly being used to elucidwrc the
mcchnnisms of EBV-specific lymphomagenesis and to
assess novel therapeutic approaches.
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Citation
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