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Long non-coding RNA XIST promotes the malignant features of oral squamous cell carcinoma (OSCC) cells through regulating miR-133a-5p/VEGFB

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dc.contributor.authorWu, Kankui
dc.contributor.authorWu, Mengxuan
dc.contributor.authorWu, Wancui
dc.contributor.authorLiu, Wenzhe
dc.date.accessioned2023-03-08T16:47:54Z
dc.date.available2023-03-08T16:47:54Z
dc.date.issued2023
dc.description.abstractObjective. Oral squamous cell carcinoma (OSCC) represents a frequently seen oral cavity malignancy, and the mechanisms of its occurrence and development remain unclear. The present work examined the expression and biological function of long non-coding RNA (lncNRA) XIST (X-inactive specific transcript) in OSCC cells and tissues. Study design. A total number of 50 OSCC and paired non-carcinoma tissue samples were collected in this study. Gene expression levels in cancer tissues and cells were quantified by RT-qPCR. In addition, gain- and loss-of-function experiments were conducted to investigate the biological roles of XIST as well as its downstream targets in OSCC cells. Results. XIST was upregulated in OSCC cells and tissues, which predicted a poorer prognostic outcome in OSCC patients. Silencing XIST inhibited the growth and invasion of OSCC cells and triggered apoptosis. miR133a-5p was identified as a downstream target of XIST, which was downregulated in OSCC tissues. miR-133a5p mediated the effect of XIST by targeting VEGFB. VEGFB overexpression rescued the inhibitory effects of XIST silencing on cell growth, invasion and migration. Conclusion. Taken together, the above data indicates that XIST serves as an oncogenic factor to enhance the growth and invasion ofes
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dc.format.extent14es
dc.identifier.citationHistology and Histopathology Vol. 38, nº1 (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-504
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/129210
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectXISTes
dc.subjectLong non-coding RNAes
dc.subjectOCes
dc.subjectmiR133a-5pes
dc.subjectVEGFBes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleLong non-coding RNA XIST promotes the malignant features of oral squamous cell carcinoma (OSCC) cells through regulating miR-133a-5p/VEGFBes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38, nº1 (2023)