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Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gastrointestinal stromal tumours

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dc.contributor.authorTorres de Oliveira, Antônio Talvane
dc.contributor.authorReis, Rui M.
dc.contributor.authorAlfonso, Julieta
dc.contributor.authorMartinho, Olga
dc.contributor.authorMatos, Delcio
dc.contributor.authorLopes Carvalho, André
dc.contributor.authorBuosi Silva, Thiago
dc.contributor.authorScapulatempo, Cristovam
dc.contributor.authorSydney Saad, Sarhan
dc.contributor.authorLongatto-Filho, Adhemar
dc.date.accessioned2016-05-03T14:51:03Z
dc.date.available2016-05-03T14:51:03Z
dc.date.issued2011
dc.description.abstractThis study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), and to analyse the value of lymphatic vessel density (LVD) in a tumour that is believed to preferentially metastasize through blood vessel conduits. A panel of immunohistochemical antibodies was used to evaluate 51 cases of genetically characterised GISTs: VEGF-C, VEGFR-3, D2-40 (for LVD assessment) and CD31 (for blood vessel density – BDV – assessment). The results were correlated with the clinical-pathological data. The large majority of cases (86.2%; 44/51) showed a mutation of the KIT gene, most of them (72.5%; 37/51) revealing mutations in exon 11. VEGFR-3 was predominantly expressed in KIT mutated GISTs (p=0.019). High LVD was correlated with the absence of metastasis (p=0.010) and high BVD showed a positive correlation with the occurrence of metastasis (p=0.049). The strong expression of VEGF-C and VEGFR-3 in GIST’s cells was not correlated with the clinical parameters of aggressiveness, nor with high LVD.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/49526
dc.languageenges
dc.publisherF. Hernández y J.F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología.es
dc.relation.ispartofHistology and histopathology, Vol. 26, nº12 (2011)es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectGastrointestinal stromal tumores
dc.subjectKITes
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleLymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gastrointestinal stromal tumourses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.26,nº12 (2011)