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New Insights into the Mammalian Egg Zona Pellucida

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dc.contributor.authorChevret, Pascale
dc.contributor.authorAlgarra, Blanca
dc.contributor.authorGonzález-Brusi, Leopoldo
dc.contributor.authorCots Rodríguez, Paula
dc.contributor.authorIzquierdo Rico, María José
dc.contributor.authorAvilés Sánchez, Manuel
dc.contributor.authorJíménez Movilla, María
dc.contributor.authorMoros Nicolás, Carla
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2024-01-23T17:03:33Z
dc.date.available2024-01-23T17:03:33Z
dc.date.issued2021
dc.description©2021. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published, version of a Published Work that appeared in final form in International Journal of Molecular Sciences. To access the final edited and published work see https://doi.org/10.3390/ijms22063276es
dc.description.abstractMammalian oocytes are surrounded by an extracellular coat called the zona pellucida (ZP), which, from an evolutionary point of view, is the most ancient of the coats that envelope vertebrate oocytes and conceptuses. This matrix separates the oocyte from cumulus cells and is responsible for species-specific recognition between gametes, preventing polyspermy and protecting the preimplantation embryo. The ZP is a dynamic structure that shows different properties before and after fertilization. Until very recently, mammalian ZP was believed to be composed of only three glycoproteins, ZP1, ZP2 and ZP3, as first described in mouse. However, studies have revealed that this composition is not necessarily applicable to other mammals. Such differences can be explained by an analysis of the molecular evolution of the ZP gene family, during which ZP genes have suffered pseudogenization and duplication events that have resulted in differing models of ZP protein composition. The many discoveries made in recent years related to ZP composition and evolution suggest that a compilation would be useful. Moreover, this review analyses ZP biosynthesis, the role of each ZP protein in different mammalian species and how these proteins may interact among themselves and with other proteins present in the oviductal lumen.es
dc.formatapplication/pdfes
dc.format.extent20es
dc.identifier.citationInternational Journal of Molecular Sciences
dc.identifier.doi10.3390/ijms22063276.
dc.identifier.issn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10201/137629
dc.languageenges
dc.relationPGC2018-094781-B-I00 (MCINN/AEI/FEDER, UE) and Fundación Seneca-Agencia de Ciencia y Tecnología de la Región de Murcia “Ayudas a la realización de proyectos para el desarrollo de investigación científica y técnica por grupos competitivos 2018” (20887/PI/18).es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectZona pellucidaes
dc.subjectZPes
dc.subjectPseudogenizationes
dc.subjectCompositiones
dc.subjectMolecular evolutiones
dc.subjectMammalses
dc.titleNew Insights into the Mammalian Egg Zona Pellucidaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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