Publication: New Insights into the Mammalian Egg Zona Pellucida
Authors
Chevret, Pascale ; Algarra, Blanca ; González-Brusi, Leopoldo ; Cots Rodríguez, Paula ; Izquierdo Rico, María José ; Avilés Sánchez, Manuel ; Jíménez Movilla, María ; Moros Nicolás, Carla
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DOI
10.3390/ijms22063276.
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info:eu-repo/semantics/article
Description
©2021. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/
This document is the Published, version of a Published Work that appeared in final form in International Journal of Molecular Sciences. To access the final edited and published work see https://doi.org/10.3390/ijms22063276
Abstract
Mammalian oocytes are surrounded by an extracellular coat called the zona pellucida
(ZP), which, from an evolutionary point of view, is the most ancient of the coats that envelope
vertebrate oocytes and conceptuses. This matrix separates the oocyte from cumulus cells and is
responsible for species-specific recognition between gametes, preventing polyspermy and protecting
the preimplantation embryo. The ZP is a dynamic structure that shows different properties before
and after fertilization. Until very recently, mammalian ZP was believed to be composed of only three
glycoproteins, ZP1, ZP2 and ZP3, as first described in mouse. However, studies have revealed that
this composition is not necessarily applicable to other mammals. Such differences can be explained
by an analysis of the molecular evolution of the ZP gene family, during which ZP genes have suffered
pseudogenization and duplication events that have resulted in differing models of ZP protein
composition. The many discoveries made in recent years related to ZP composition and evolution
suggest that a compilation would be useful. Moreover, this review analyses ZP biosynthesis, the
role of each ZP protein in different mammalian species and how these proteins may interact among
themselves and with other proteins present in the oviductal lumen.
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International Journal of Molecular Sciences
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