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Quantitative immunohistochemical assessment of blood and lymphatic microcirculation in cutaneous lichen planus lesions

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dc.contributor.authorVýbohová, Desanka
dc.contributor.authorMellová, Yvetta
dc.contributor.authorAdamicová, Katarína
dc.contributor.authorAdamkov, Marián
dc.contributor.authorHešková, Gabriela
dc.date.accessioned2020-09-18T09:07:41Z
dc.date.available2020-09-18T09:07:41Z
dc.date.issued2015
dc.description.abstractLatest advances have brought to light the hypothesis that angiogenesis and lymphangiogenesis are tightly connected to some chronic inflammatory diseases. The present study focuses on immunohistochemical assessment of the quantitative changes in the blood and lymphatic microcirculatory bed in common chronic dermatosis - cutaneous lichen planus. Double immunohistochemistry with CD34 and podoplanin antibodies was used to detect blood and lymphatic endothelium, while anti-human VEGF was used for the observation of a key angiogenesis and lymphangiogenesis inducer. Morphometric analysis was performed with QuickPhoto Micro image analysis software. Results confirmed statistically significant enlargement of both the blood and lymphatic microcirculatory beds. Compared to healthy skin, cutaneous lichen planus lesions revealed 1.6 times enlarged blood microcirculatory bed and 1.8 times enlarged lymphatic microcirculatory bed. Vascular endothelial growth factor (VEGF) expression in lesional skin was significantly higher in the epidermis (19.1 times increase) than in the dermis (10.3 times increase). These findings indicate a tight association of angiogenesis and lymphangiogenesis with the pathogenesis of cutaneous lichen planus.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationHistology and Histopathology, vol.30, nº 6, (2015)
dc.identifier.doi10.14670/HH-30.697
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/96125
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCutaneous blood and lymphatic microcirculationes
dc.subjectCutaneous lichen planuses
dc.subjectAngiogenesises
dc.subjectLymphangiogenesises
dc.subjectVEGFes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleQuantitative immunohistochemical assessment of blood and lymphatic microcirculation in cutaneous lichen planus lesionses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.30, nº6 (2015)