Publication: lmmunohistochemical analysis for cell proliferation-related protein expression in small cell carcinoma of the esophagus a comparative
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Date
1999
Authors
Okudela, K. ; Ito, T. ; Kameda, Y. ; Nakamura, N. ; Kitamura, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Small cell carcinoma is a rare neoplasm in
the esophagus. To evaluate cell proliferation activity and
its underlying mechanisms in this tumor, we examined
immunohistochemically 5 cases of small cell carcinoma
of the esophagus (SCCE) for expressions of tumor
suppressor proteins, oncoproteins and cell proliferation
markers including p53, p21WAF1/C1P1r,e tinoblastoma
(Rb) protein, bcl-2, Ki-67 and PCNA, and compared the
results with those of 5 cases of small cell carcinoma of
the lung (SCCL) and 10 cases of squamous cell
carcinoma of the esophagus (SQCE). The prevalence
and labeling index of p53-immunoreactivity tended to
be higher in SCCE (415; 56.6%) and SCCL (415;
79.9%) than in SQCE (6110; 48.8%). Expression of
p21wAFl/C1P1w as observed in 2 of 10 cases of SQCE.
In contrast, its expression could not be detected in any
cases of SCCE and SCCL examined. Expression of Rb
protein was observed in 9 out of 10 cases of SQCE, but
not in any cases of SCCE and SCCL. SCCE and SCCL
showed more frequent and intense immunoreactivity for
bcl-2 than SQCE. In expression of cell proliferation
markers (Ki-67 and PCNA), no remarkable difference
was observed among SCCE, SCCL and SQCE. These
results suggest that SCCE and SCCL could share some
genetic alternations including mutation of p53, loss of
Rb gene and overexpression of bcl-2, and these may be
related to the similar biological potentials between the
two. Futhermore, SCCE was different from SQCE in
expression of Rb protein and bcl-2, and these two types
of esophageal carcinoma could arise through different
molecular mechanisms.
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