Publication: Effect of nitrendipine, a calcium antagonist, on cell volumen in rat salivary glands after isoproterenol stimulation
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Date
1991
Authors
Carter, Laurie C. ; Nickerson, Peter A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Four days of isoproterenol injections induced
a marked enlargement of the rat parotid and
submandibular glands reflected in significant increases in
the absolute and relative wet and dry weight of the
glands. The enlargement in parotid gland was
attributable at least in part to cellular hypertrophy
inasmuch as the average volume per cell of acinar cells
increased. In contrast, the average volume of acinar cells
in the submandibular gland was decreased as compared
to that of control. It is likely that hyperplasia in both
groups accounts in part for the enlargement. The slow
calcium channel is unlikely involved in the isoproterenolinduced
stimulation of the gland, inasmuch as the
calcium channel antagonist did not modify the
enlargement of the parotid or submandibular glands.
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Citation
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